Anybody know of a disease that causes this?
Answer:
Hereditary Sensory Autonomic Neuropathies, abbreviated HSAN. They have been classified into five varieties, HSAN1-5 based on their clinical features and associated genes, although there are cases that don't fall into any of the five categories.
HSAN1 typically appears in childhood or young adulthood. It is a progressive loss of all sensory types (pain & temperature first, then touch, and vibration & proprioception last) and sometimes motor functions. Usually starts in the feet.
HSAN2 is similar in presentation to HSAN1, but doesn't involve vibration or proprioception.
HSAN3, or Riley-Day Syndrome, involves loss of pain & temperature sensation and impairment of autonomic regulation.
HSAN4, or congenital insensitivity to pain with anhidrosis, involves loss of pain & temperature sensation beginning in infancy. Also has problems maintaining a normal body temperature.
HSAN5 also involves loss of pain & temperature sensation, but that's it.
In general, loss of sensation--particularly pain--leads to very bad things. People who can't feel pain can't feel when they get injured. As a result, people with these problems will frequently be missing fingers, have lips and tongues that have been bitten repeatedly, and scratched up corneas.
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