Pls take action on this chronicle... your hostile response would be a great give a hand...gratitude God Bless?
ScienceDaily (July 7, 2008) — A new treatment using a combination of drugs targeting different parts of the immune system improve the recovery rate for patients with severe lupus involving the kidneys, according to a current report.
"In our study, multi-target therapy is shown to be superior to traditional therapy for inducing complete remission of class V+IV lupus nephritis, next to few side effects," comments Dr. Lei-Shi Li of the Research Institute of Nephrology of Jinling Hospital, Nanjing University School of Medicine in Nanjing,China.
The study included 40 patients with severe lupus nephritis. Lupus nephritis is inflammation of the kidneys occurring contained by patients with the immune system disease systemic lupus erythematosus (SLE). All patients had "class V+IV" disease, classification widespread inflammation and decreasing function of the kidneys. "This is a severe form of lupus nephritis that is traditionally treated beside a single immunosuppressant drug, but the efficacy is very poor," says Dr. Li. "We considered that, since the impact of severe SLE on the kidney involves sundry parts of the immune system, it is necessary to treat the different immune targets next to a combination of immunosuppressant drugs."
One group of patients received this "multi-target" therapy, consisting of the immunosuppressant drugs tacrolimus and mycophenolate mofetil--commonly used as anti-rejection drugs in transplant patients--plus a steroid. The other group received standard treatment beside a single immunosuppressant drug (cyclophosphamide).
The complete remission rate, with recovery of majority kidney function, was about four times greater among patients receiving the three-drug combination. "For patients receiving multi-target psychoanalysis, the complete remission rate reached 65 percent at nine months, versus only 15 percent underneath traditional therapy," says Dr. Li.
Some patients contained by both groups had partial remission, with some return of kidney function. Overall, 95 percent of patients surrounded by the multi-target therapy group had partial or complete remission, compared to 55 percent next to single-drug therapy. The rate of most adverse effects was also lower next to multi-target therapy.
Systemic lupus erythematosus is an autoimmune disorder, in which the immune system attacks clean organs and tissues. By reducing immune system activity, treatment with immunosuppressant drugs have improved most outcomes for patients with SLE. However, class V+IV lupus nephritis continues to be a most important problem--it has a poor response to traditional treatments and can lead to long-lasting kidney damage. "The prognosis is very poor, so it is significant for us to develop a new regimen for the treatment of this type of lupus nephritis," says Dr. Li.
Using a combination of drugs that affect different immune target, multi-target therapy improves the likelihood of remission for patients with severe lupus nephritis. "The therapeutic effect of our multi-target psychoanalysis is apparently superior to traditional therapy for inducing complete remission of Class V+IV lupus nephritis, and also bears angelic tolerance under relatively lower dosages," Dr. Li adds.
The authors stress that their study is solely preliminary. The study includes a small group of patients from a single hospital, with a relatively short follow-up time. Larger randomized trials with longer follow-up are required.
Answers: ok, a record on lupus
intersting if your an immunologist or for this type of lupus a nephrologist or just interested in lupus
Related Questions...