Why antifungal drugs resembling amphotericin is used within forgiving of meninggitis and kala-azar?
Answers:
If you suspect the patient enjoy CNS fungal infection, then you would use amphotericin, or liposomal amphotericin these days, since amphotericin is really fading out of the open market. As far as I know, people use liposomal amphotericin for CNS fungal infection for presumed better permeation. There's some case reports surrounded by the literature. Newer generation anti-fungal drugs such as fluconazole and voriconazole hold also been used, but depends on what type of fungal infection the tolerant has.
Posaconazole is another powerful anti-fungal on the horizon.
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