I would resembling to know the mode of movements of Acyclovir and Valacyclovir on the DNA virus?
Answers:
Acyclovir and valacyclovir are homologues of DNA nucleotides. There is a particular enzyme encoded by HSV and VZV which begin a cascade of biochemical reaction that allows the drug to be inserted in a growing DNA manacle in place of the innate nucleotide. The chemical structure of the drug is such that once it becomes incorporated into the DNA, no further basis can be added to the DNA and the replication must stop. As a result of this, cells infected by the virus cannot replicate and will die, while the uninfected cell will (ideally) be left along by the drug.
Affinity for the enzyme thymidine kinase: http://www.rxlist.com/cgi/generic3/valac. . Please contact me - I want to know why you are interested contained by this - its something I study too - thanks.
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