Some drugs gears question? relating to anxiety?
(b)Which receptor is the target for this class of drugs? (1 mark)
(c)Describe how these drugs affect this receptor. (3 marks)
(d)Describe how the elevated plus (or cross) maze can be used to determine whether a drug reduce anxiety in rats. (2 marks)
(e)How can you benchmark anxiety in humans by experimental methods? (1 mark)
(f)Barbiturates are no longer used to treat anxiety. What are they still used for? (2 marks)
Answers:
1. benzodiazepines
2. GABA
3. open GABA receptors to hyperpolarize neuron
4. no idea
5. activation of sympathetic system: heart rate and breathing increases, dry mouth, etc...
6. sedation chiefly (probably some other stuff too)
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