How do diuretics work? what are the 3/4 foremost groups?
Answers:
Loop diuretics work by blocking sodium reabsoption in the Loop of Henle surrounded by the kidney. Since sodium is the major contributor to the osmotic slant, this prevents the kidneys from concentrating the urine leading to increased urine output. A commonly used loop diuretic is furosemide (Lasix)
Thiazide diuretics work within a similar way by blocking sodium reabsorption but contained by this case at the distal tubule. A commonly used thiazide is hydrochlorthiazide.
Osmotic diuretics work as a solute that can be filter through the kidney but not be reabsorbed. This keeps hose in the filtrate main to increased urine output. An example of this is mannitol.
The fourth class is the potassium-sparing diuretics like spironolactone. They are aldosterone antagonists and increase the excretion of sodium
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